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The heavy atom effect on photocleavage of DNA by mono-hydroxyl halogenated corroles |
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| Authors: | Lei Shi Huan Feng Jiang Hai Yang Liu Li Ping Si Kai Mei Peng Li Li You Hui Wang Lei Zhang Liang Nian Ji Chi Kwong Chang |
| Institution: | a Department of Chemistry, South China University of Technology, Guangzhou 510641, China;b State Key Laboratory of Optoelectronics Materials and Technologies/MOE Laboratory of Bioinorganic and Synthetic Chemsitry, Sun Yat-Sen University, Guangzhou 510275, China;c Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China |
| Abstract: | DNA photocleavage properties of halogenated mono-hydroxyl corrole 1-5 were investigated. It was found that these corroles were able to photocleavage supercoiled pBR 322 DNA(SC) into nicked-circular DNA(NC). The activity of these corroles follows an order of4>3>2»1>5. The photosensitized singlet oxygen (Ф△) quantum yield by these corrolesalso follows that same order, showing the photocleavage activity is related to the heavy atom effect of halogen atoms on corroles. |
| Keywords: | Corrole DNA Photocleavage Heavy atom effect |
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