Spectrophotometric Quantitation of Fluoxetine Hydrochloride Using Benzoyl Peroxide and Potassium Iodide |
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Authors: | Islam Ullah Khan Tehseen Aman Muhammad Asif Iqbal Asrar Ahmad Kazi |
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Institution: | (1) Department of Chemistry, Government College, Lahore, Pakistan, PK;(2) Pakistan Council of Scientific and Industrial Research Laboratories Complex, Lahore, Pakistan, PK |
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Abstract: | Fluoxetine hydrochloride reacts with benzoyl peroxide and potassium iodide, after heating for 1 min at 30 °C, to give a blue
colour having maximum absorbance at 570 nm. The reaction is selective for fluoxetine with 0.01 mg/mL as visual limit of quantitation
and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer’s law from 0.1 mg/10 mL to
2.0 mg/10 mL of fluoxetine and the relative standard deviation is 0.68%. The qualitative assessment of tolerable amounts of
other drugs is also studied.
Received September 21, 1998. Revision September 10, 1999. |
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Keywords: | : Fluoxetine hydrochloride spectrophotometry pharmaceutical analysis |
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