Total Synthesis of C-8-Geranylflavonoids

Geranylflavonoids are interesting natural products isolated in recent years from some traditional medicinal plants. Some of these flavanoids have been reported to exhibit hypotensive, antibacterial and antitumor effects¹. With respect to the synthesis of geranylflavonoids, only the 8-geranylflavanone skeleton as found in compounds 1², 2³ and 3⁴ has not been yet prepared.