| 主链含氨基酸、5-氟尿嘧啶和膦甲酸乙酯(膦乙酸乙酯)的聚磷酰胺和聚磷酸酯的合成及抗肿瘤活性研究 |
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| 引用本文： | 赵儒林,范昌烈,卓仁禧.主链含氨基酸、5-氟尿嘧啶和膦甲酸乙酯(膦乙酸乙酯)的聚磷酰胺和聚磷酸酯的合成及抗肿瘤活性研究[J].功能高分子学报,1989(3). |
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| 作者姓名： | 赵儒林 范昌烈 卓仁禧 |
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| 作者单位： | 武汉大学化学系
(赵儒林，范昌烈)，武汉大学化学系(卓仁禧) |
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| 摘 要： | 由1,3-双(氨基酸丙酯盐酸盐)-5-氟尿嘧啶与膦甲(乙)酸乙酯在DMF中反应制得二十种主链含氨基酸、膦甲(乙)酸乙酯和5-氟尿嘧啶三组分的聚合物。通过核磁、红外和紫外光谱以及元素分析测定了聚合物的结构。并试验了聚合物的体外抗肿瘤活性。
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| 关 键 词： | 抗肿瘤药物 5-氟尿嘧啶 氨基酸 聚磷酰胺 聚磷酸酯 |
Synthesis and Antitumor Activit of Polyphosphoramides and Polyphosphates Containning Amino Acid,5-Flcorouracil and Phosphonoformate or Phosphonoacetate |
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| Zhao Rulin,Fan Changlie,Zhuo Renxi.Synthesis and Antitumor Activit of Polyphosphoramides and Polyphosphates Containning Amino Acid,5-Flcorouracil and Phosphonoformate or Phosphonoacetate[J].Journal of Functional Polymers,1989(3). |
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| Authors: | Zhao Rulin Fan Changlie Zhuo Renxi |
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| Institution: | Zhao Rulin,Fan Changlie,Zhuo Renxi Department of Chemistry,Wuhan University,Wuhan |
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| Abstract: | Twenty new polyphosphoramides and polyphosphates were peepared from aminoacid 5--fluorouracil--1, 3--dipropylesters with (ethoxyacetyl) phosphonic dichloride or(ethoxycarbonyl) phosphonic dichloride in DMF in vacuo or in the presence of Et_3N.The polymers were structureally characterized by ~1H NMR, IR and UV as well aselemental analysis. The antitumor activity of all of the polymes were tested againstEAC in vitro. The preliminary results indicate that the polymers containing valine,serine, phenylalanine and tyrosine have better antitumor activity. |
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| Keywords: | Antitumor activity 5-fluorouacil Amino acid Polyphosphoramides Polyphsphates |
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