Chemical and bioactivity evaluation of the bark of Neonauclea purpurea |
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Authors: | Karaket Netiya Supaibulwatana Kanyaratt Ounsuk Supatsara Bultel-Poncé Valérie Pham Van Cuong Bodo Bernard |
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Institution: | Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. |
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Abstract: | Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and alpha-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC50 values of 6.6 and 11.3 microM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC50 value of 1.19 microM. |
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