| 对烷氧基取代 MeO-BIPHEP 型手性双膦钌配合物催化 β-酮酸酯不对称加氢反应 |
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| 引用本文： | 彭宗海,马梦林,付海燕,陈华,李贤钧.对烷氧基取代 MeO-BIPHEP 型手性双膦钌配合物催化 β-酮酸酯不对称加氢反应[J].催化学报,2010,31(2):191-194. |
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| 作者姓名： | 彭宗海 马梦林 付海燕 陈华 李贤钧 |
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| 作者单位： | 1. 四川大学化学学院有机金属络合催化研究所,教育部绿色化学与技术重点实验室,四川成都,610064
2. 四川大学化学学院有机金属络合催化研究所,教育部绿色化学与技术重点实验室,四川成都,610064;西华大学化学系,四川成都,611930 |
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| 摘 要： | 报道了对烷氧基取代的 MeO-BIPHEP 型手性双膦配体钌配合物催化的β-酮酸酯不对称加氢反应, 考察了反应温度、压力、底物/催化剂摩尔比和溶剂对反应的影响. 结果表明, 在乙醇中该配合物催化 3-丁酮酸乙酯加氢反应的对映选择性达 98.0%,且对含不同取代基的β-酮酸酯均表现出较高的活性和对映选择性.
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| 关 键 词： | β-酮酸酯 不对称加氢 联苯类配体 钌配合物 |
| 收稿时间： | 2010-02-25 |
Asymmetric Hydrogenation of β-Ketoesters Catalyzed by Ru Complex with Para-alkoxy Substituted MeO-BIPHEP Type Diphosphine Ligands |
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| PENG Zonghai,MA Menglin,FU Haiyan,CHEN Hua,LI Xianjun.Asymmetric Hydrogenation of β-Ketoesters Catalyzed by Ru Complex with Para-alkoxy Substituted MeO-BIPHEP Type Diphosphine Ligands[J].Chinese Journal of Catalysis,2010,31(2):191-194. |
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| Authors: | PENG Zonghai MA Menglin FU Haiyan CHEN Hua LI Xianjun |
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| Institution: | 1Key Laboratory of Green Chemistry and Technology of Ministry of Education, Institute of Homogeneous Catalysis, Faculty of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China 2Department of Chemistry, Xihua University, Chengdu 611930, Sichuan, China |
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| Abstract: | A series of optically active MeO-BIPHEP type ligands, (R)-6,6'-dimethoxy-2,2'-bis(di-p-alkoxyphenyl-phosphine)-1,1'-biphenyl, were synthesized, and the ruthenium complex with these ligands, Ru(diphosphine)(C_6H_6)Cl]Cl, was applied for the asymmetric hydrogena-tion of β-ketoesters. Influence of temperature, pressure, substrate/catalyst molar ratio, and solvents was tested. The results showed that the 98.0% of ee value was achieved for the hydrogenation of ethyl acetoacetate in EtOH. Ru(diphosphine)(C_6H_6)Cl]Cl showed high catalytic activity and enantioselectivity for the asymmetric hydrogenation of various β-ketoesters. |
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| Keywords: | asymmetric hydrogenation biaryl phosphine ligand ruthenium complex |
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