Voltammetric Detection of Captopril in a Commercial Drug Using a Gold-Copper Metal-organic Framework Nanocomposite Modified Electrode |
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Authors: | Diana Maria da Silva Madalena Carneiro da Cunha Areias |
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Institution: | Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, Av. Jornalista Anibal Fernandes, s/n° Cidade Universitária – Recife, PE – CEP 50.740-560, 50.740-560 Recife, Brazil |
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Abstract: | We report the application of an electrochemical sensor based on gold-copper metal-organic framework immobilized on the surface of a glassy carbon electrode to the detection of captopril (CAP), an angiotensin-converting enzyme inhibitor. Cyclic voltammetric studies showed that the joint action of gold nanoparticles and copper-1,3,5-benzenetricarboxylate (Cu−BTC) enhanced the electrochemical response to the Cu-captopril complex that is adsorbed onto the surface of the electrode. Release of gold nanoparticles from Au@Cu−BTC not only increased the conductivity of the electrode but also provided a more favorable environment for the deposition of reduced Cu that is catalytically renewed on the electrode surface. The anodic current of the Cu(II)−CAP oxidation peak varied linearly within two concentration ranges, namely 0.5 to 7.0 μmol L−1 and 10 to 2500 μmol L−1, with a limit of detection of 0.047 μmol L−1. The mean recovery for the determination of captopril in commercial tablets was 100.3 % suggesting that the method has considerable potential for future industrial applications. |
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Keywords: | Captopril modified glassy carbon electrode gold-copper-1 3 5-benzenetricarboxylate nanocomposite cyclic voltammetry |
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