| Institution: | 1. Université de Reims Champagne-Ardenne, ICMR UMR CNRS 7312, BP 1039, FR-51687 Reims cedex 2, France
Chimie ParisTech, PSL University, UMR CNRS 8247, Institut de Recherche de Chimie Paris, FR-75005 Paris, France;2. Université de Reims Champagne-Ardenne, ICMR UMR CNRS 7312, BP 1039, FR-51687 Reims cedex 2, France |
| Abstract: | As a proof of concept, we demonstrate in this preliminary study that 3O2 could be used as magnetic Contrast Agent (CA) to monitor photodynamic treatments (PDT). In this purpose, and using a well-studied Photo-Sensitizer (PS) from our team ( Ruteg ), we highlighted that the combined action of the PS and irradiation led to significant changes in T1 (and R1) values of the protons of the water molecules. We assume that with these conclusive results using relaxometric measurements, transposition to Magnetic Resonance Imaging (MRI) in pertinent conditions (oxygen concentration, magnetic field) should be achievable. |
