Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi |
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Authors: | Saeidnia Soodabeh Gohari Ahmad Reza Uchiyama Nahoko Ito Michiho Honda Gisho Kiuchi Fumiyuki |
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Institution: | Department of Pharmacy, Faculty of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran. |
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Abstract: | From the whole plant of Dracocephalum kotschyi BOISS., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1-8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), beta-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-beta-D-glucopyranoside (9), and limonen-10-ol 10-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (10). Compounds 1 (3.1 microM), 2 (3.1 microM), 3 (3.1 microM), 5 (6.2 microM), 6 (6.2 microM), and 8 (6.2 microM) were effective against epimastigotes of Trypanosoma cruzi. |
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