Synthesis,characterization and anticancer activity of new palladacycles derived from chiral α‐diimines |
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| Authors: | Sandra Cruz Sylvain Bernès Pankaj Sharma Rosa Vazquez Guadalupe Hernández Roberto Portillo René Gutiérrez |
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| Affiliation: | 1. Lab. Síntesis de Complejos. Fac. Ciencias Químicas, Universidad Autónoma de Puebla, PO Box 1067, C.P. 72001, Puebla, Pue., México;2. Departamento Ing. Química, Universidad Politécnica de Tlaxcala, Calle 21, no. 611, Col. La Loma Xicohténcatl, Tlaxcala, Tlax. México;3. DEP, Faculdad Ciencias Químicas, UANL Guerrero y Progreso S/N Col. Trevi?o 64570, Monterrey, N.L. México;4. Instituto de Química‐UNAM, Circuito exterior, Cd. Universitaria, Coyoacán, C.P. 04510, D.F., México |
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| Abstract: | Optically pure α‐diimines quantitatively obtained in solvent‐free conditions starting from 2,3‐butanedione and (S)‐(?)‐1‐phenylethylamine and (S)‐(?)‐1‐(4‐methylphenyl)ethylamine, respectively, yielded the new chiral mono‐Pd complexes 2a–b, which have been partly characterized by IR, 1H‐ and 13C‐NMR spectroscopies along with MS‐FAB+ spectrometry. The crystal and molecular structure for palladacycle 2a has been fully confirmed by single‐crystal X‐ray studies. Studies in vitro of 2a–b have displayed growth inhibition against different classes of cancer: leukemia (K‐562 CML), colon cancer (HCT‐15), breast cancer (MCF‐7), central nervous system (U‐251 Glio) and prostate cancer (PC‐3) cell lines. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | anticancer activity chiral α ‐diimines Pd complexes |
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