| Synthesis
of Pyrrole-Imidazole Polyamide |
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| 作者姓名： | Jun Hua XIAO Gu YUAN Wei Qiang HUANG Fei Li TANG Albert S. C. CHAN K.L. Daniel LEE |
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| 作者单位： | Bioorganic Molecular Engineering Laboratory，Department of Chemistry，Peking University，Beijing 100871 Department of Applied Biology and Chemical Technology，The Hon |
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| 基金项目： | Professor Pang Zhang for his encouragement，the National Natural Science Foundation of China !298 |
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| 摘 要： | Small molecules that target specific predetermined DNA sequences have the potential tocontrol gene expression'. Realization of the high affinity binding and specific recognitionof DNA sequences by organic molecules is one of the focuses of biological chemistry.The natural products netropsin and distamycin are N-methylpyrrole containing di- andtripeptides, with binding specificity at sites of successive A.T or T.A base pairs of DNAin the minor groove'. Recently, N-methylimidazole is intro…
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Synthesis of Pyrrole-Imidazole Polyamide |
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| Jun Hua XIAO,Gu YUAN,Wei Qiang HUANG,Fei Li TANG Albert S. C. CHAN,K.L. Daniel LEE.Synthesis
of Pyrrole-Imidazole Polyamide[J].Chinese Chemical Letters,2000,11(3):207-208. |
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| Authors: | Jun Hua XIAO Gu YUAN Wei Qiang HUANG Fei Li TANG Albert S C CHAN KL Daniel LEE |
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| Abstract: | One simple and versatile method is established for the synthesis of DNA recognition molecules-polyamides containing alternating N-methylpyrrole and N-methylimidazole without necessitating NH_(2-) group protection. |
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| Keywords: | Polyamides DNA recognition molecules pyrroles and imidazoles |
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