Transformed steroids. 176. Paths of transformation of 17a-ethynyl-17β-hydroxyandrostenes into Δ16-21-hydroxy-20-ketopregnenes |
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| Authors: | A M Turuta T M Fadeeva A V Kamernitskii Lu Dyk Chi |
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| Institution: | (1) N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow |
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| Abstract: | A novel method in steroid chemistry for synthesis of pregna-4,16-dien-3-one-20-yne and pregna-5,16-dien-3 -ol-20-yne, based on the dehydration of Co-complexes of the corresponding 17 -ethynyl-17-carbinols was investigated. The theoretical possibility of using phenyliodoso trifluoroacetate for the preparative transformation  16-17-ethynyl steroids into 21-hydroxy-16-20-ketopregnanes was discovered.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2810–2815, December, 1989. |
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