Thermal
behavior of loratadine |
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Authors: | L A Ramos É T G Cavalheiro |
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Institution: | 1.Departamento de Química e Física
Molecular, Instituto de Química de S?o Carlos,Universidade de S?o Paulo,S?o
Carlos,Brazil |
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Abstract: | Simultaneous
thermogravimetry (TG) and differential thermal analysis (DTA) techniques were
used for the characterization the thermal degradation of loratadine, ethyl-4-(8-chloro-5,6-dihydro-11H-benzo5,6]cyclohepta1,2-b]pyridin-11-ylidine)-1-piperidinecarboxylate.
TG analysis revealed that the thermal decomposition occurs in one step in
the 200–400°C range in nitrogen atmosphere. DTA and DSC curves showed
that loratadine melts before the decomposition and the decomposition products
are volatile in nitrogen. In air the decomposition follows very similar profile
up to 300°C, but two exothermic events are observed in the 170–680°C
temperature range.
Flynn–Wall–Ozawa method was used
for the solid-state kinetic analysis of loratadine thermal decomposition.
The calculated activation energy (E
a)
was 91±1 kJ mol–1 for α between
0.02 and 0.2, where the mass loss is mainly due to the decomposition than
to the evaporation of the decomposition products. |
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Keywords: | decomposition kinetic DTA loratadine thermogravimetry |
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