| Highly Enantioselective Phenylacetylene Addition to Benzaldehyde Catalyzed by Chiral Tridentate Ligand |
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| 引用本文： | KANG,Yong-Feng LIU,Lei YAN,Wen-Jin XU,Zhao-Qing ZHOU,Yi-Feng HAN,Zhi-Jian NI,Ming DA,Chao-Shan WANG,Rui. Highly Enantioselective Phenylacetylene Addition to Benzaldehyde Catalyzed by Chiral Tridentate Ligand[J]. 有机化学, 2004, 24(Z1): 163 |
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| 作者姓名： | KANG Yong-Feng LIU Lei YAN Wen-Jin XU Zhao-Qing ZHOU Yi-Feng HAN Zhi-Jian NI Ming DA Chao-Shan WANG Rui |
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| 作者单位： | KANG,Yong-Feng（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） LIU,Lei（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） YAN,Wen-Jin（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） XU,Zhao-Qing（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） ZHOU,Yi-Feng（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） HAN,Zhi-Jian（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） NI,Ming（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） DA,Chao-Shan（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） WANG,Rui（State Key Laboratory of Applied Organic Chemistry, Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000） |
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| 摘 要： | Development of new or improved methods for the asymmetric preparation of chiral propargylic alcohols has gained considerable significance during the past years because they are useful building blocks for the synthesis of many biologically active compounds and natural products.[1] A series of chiral tridentate ligands were conveniently synthesized from amino acids with good yields (Scheme 1).[2] A preliminary study of the enantioselective alkynylation of benzaldehyde catalyzed by this chiral tridentate ligand was carried out and up to 83% ee of chiral propargyl alcohols was obtained (Table 1 ). A further investigation of the tridentate ligand is currently underway.
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Highly Enantioselective Phenylacetylene Addition to Benzaldehyde Catalyzed by Chiral Tridentate Ligand |
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| KANG,Yong-Feng,LIU Lei,YAN,Wen-Jin,XU,Zhao-Qing,ZHOU,Yi-Feng,HAN,Zhi-Jian,NI,Ming,DA,Chao-Shan,WANG,Rui. Highly Enantioselective Phenylacetylene Addition to Benzaldehyde Catalyzed by Chiral Tridentate Ligand[J]. Chinese Journal of Organic Chemistry, 2004, 24(Z1): 163 |
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| Authors: | KANG Yong-Feng LIU Lei YAN Wen-Jin XU Zhao-Qing ZHOU Yi-Feng HAN Zhi-Jian NI Ming DA Chao-Shan WANG Rui |
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| Abstract: | Development of new or improved methods for the asymmetric preparation of chiral propargylic alcohols has gained considerable significance during the past years because they are useful building blocks for the synthesis of many biologically active compounds and natural products.[1] A series of chiral tridentate ligands were conveniently synthesized from amino acids with good yields (Scheme 1).[2] A preliminary study of the enantioselective alkynylation of benzaldehyde catalyzed by this chiral tridentate ligand was carried out and up to 83% ee of chiral propargyl alcohols was obtained (Table 1 ). A further investigation of the tridentate ligand is currently underway. |
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