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Fast and Simple Preparation of a Sensor Based on Electrochemically Reduced Graphene Oxide (rGO) for the Determination of Zopiclone in Pharmaceutical Dosage by Square Wave Adsorptive Stripping Voltammetry (SWAdSV) |
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| Authors: | Freddy Navarro Rodrigo Segura Fernando Godoy Angel A. Martí Carolina Mascayano Maria J. Aguirre Erick Flores Jaime Pizarro |
| Affiliation: | 1. Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Santiago, Chile;2. Department of Chemistry, Materials Science and Nanoengineering, Bioengineering, Smalley-Curl Institute for Nanoscale Science and Technology, Rice University, Houston, TX 77005 United States;3. Departamento Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Santiago, Chile |
| Abstract: | The interactions of zopiclone with electrochemically reduced graphene oxide (rGO) modified electrode were examined. A comparison of GC/rGO and glassy carbon electrode (GC) by electrochemical impedance spectroscopy and scanning electrochemical microscopy (SECM) shows that the modified surface is much less conductive than GC. The role of rGO is to act as a site of specific adsorption of the analyte. Molecular dynamics showed that the monoanionic form of zopiclone presents more interactions with defects of rGO. The analytical methodology allowed obtaining a linearity of 10–130 μg L−1, with a limit of detection of 2.14 μg L−1 using SWAdSV at pH 10.0. |
| Keywords: | Electrochemically reduced graphene oxide Electrochemical analysis Z-drugs Zopiclone Molecular Dynamic. |