Oxidative C(sp3)?N Cleavage Cascade Cyclization of N-Uracil Amidines and Tertiaryamines: Switchable Divergent Synthesis of Functionalized Pyrimidouracils and Dihydropyrimidouracils |
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| Authors: | Longkun Chen Mingshuai Zhang Zhuoyuan Liu Donghan Liu Yulin Sun Prof Yongchao Wang Prof Fuchao Yu |
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| Institution: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650504 P. R. China;2. Colleage of Vocational and Technical Education, Yunnan Normal University, Kunming, 650092 P. R. China |
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| Abstract: | The divergent synthesis of dihydropyrimidouracil and pyrimidouracil derivatives from N-uracil amidines and tertiaryamines by an oxidative C(sp3)?N cleavage cascade cyclization reaction is first described. This transformation enables the formation of new C(sp3)?N and C(sp2)?N bonds via the selection of different oxidation conditions. The features of this method include tunable product selectivity, excellent chemoselectivity, readily available starting materials, broad substrate scope, good tolerance of functional groups, and moderate to high yields. |
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| Keywords: | Cascade Cyclization dihydropyrimidouracils oxidative C(sp3)?N cleavage pyrimidouracils switchable divergent synthesis |
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