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Electrochemical Sensor for Selective Detection of Meldonium in Urine by Voltammetry |
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| Authors: | Olga L Mezentseva Galina B Slepchenko Elena V Dorozhko Eugenia S Moiseeva Vladimir P Kryukovskiy Nikolay K Zaycev |
| Institution: | 1. Siberian State Medical University, Moskovsky trakt 2, 634050 Tomsk, Russian Federation;2. National Research Tomsk Polytechnic University, Lenin Avenue 30, 634050 Tomsk, Russia;3. MIREA – Russian Technological University, Vernadsky Avenue 86, 119571 Moscow, Russian Federation |
| Abstract: | A highly sensitive electrochemical sensor based on arenediazonium tosylates was designed to detect meldonium in urine. The effect of the concentration of ArN2+OTs− arenediazonium tosylate modifier and various substituents was studied. Basic operating parameters for voltammetric meldonium detection were established and the procedure for urine sample preparation was developed. The following values were obtained: limit of detection (LOD) 0.005 mg ⋅ L−1 (P=0.95) and limit of quantification (LOQ) 0.01 mg ⋅ L−1. The relationship between the analytical signal and meldonium concentration in the solution ranging from 0.01 to 400 mg ⋅ L−1 was described by a linear function. The meldonium concentration error did not exceed 18 %. The analysis time for a single urine sample was reduced to 15 minutes. |
| Keywords: | sensor arenediazonium tosylates meldonium voltammetry urine |