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Phosphine-Catalyzed [3+2] Cycloaddition of Aza-Aurones and Allenoates: Enantioselective Synthesis of 2-Spirocyclopentyl-Indolin-3-Ones |
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| Authors: | Dr. Elisa Brambilla Camilla Pozza Prof. Silvia Rizzato Prof. Giorgio Abbiati Dr. Valentina Pirovano |
| Affiliation: | 1. Dipartimento di Scienze Farmaceutiche, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, Via G. Venezian 21, 20133 Milano, Italy;2. Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133 Milano, Italy |
| Abstract: | An enantioselective phosphine-catalyzed [3+2] cycloaddition between aza-aurones and allenoates is here described. The reaction proceeded under mild reaction conditions to afford 2-spirocyclopentyl indolin-3-one derivatives as single γ-isomer and with high levels of stereocontrol. |
| Keywords: | asymmetric catalysis cycloaddition organocatalysis phosphanes spiro compounds |