Catalytic,asymmetric Strecker reactions catalysed by titaniumIV and vanadiumV(salen) complexes |
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| Affiliation: | 1. NPILPharma R+D, PO Box 521, Leeds Road, Huddersfield, West Yorkshire HD2 1GA, United Kingdom;2. School of Natural Sciences, Bedson Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, United Kingdom;3. Department of Chemistry, University Science Laboratories, South Road, Durham DH1 3LE, United Kingdom;1. Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged H-6720, Hungary;2. Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Pusztaszeri út 59-67, Budapest H-1025, Hungary;3. Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged H-6720, Hungary;4. Max-Lab, Lund University, SE-223 63 Lund, Sweden |
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| Abstract: | ![]()
VanadiumV(salen) complex 3 has been found to be an effective catalyst for the asymmetric addition of hydrogen cyanide (generated in situ from trimethylsilyl cyanide) to imines. The best results (up to 81% enantiomeric excess) were obtained for aromatic imines in which the nitrogen atom is protected with a benzyl group and in which the imine bond is not sterically encumbered. |
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