Synthesis of enantiopure 1-azaspiro[4.5]dec-6-en-8-ones from l-proline derivatives |
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| Institution: | 1. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, PR China;2. Shanghai Quality Safety Centre of Agricultural Products, Shanghai 200335, PR China;3. Molecular Microbiology Laboratory, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong |
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| Abstract: | An enantioselective synthesis of protected 1-azaspiro4.5]dec-6-en-8-one derivatives was achieved using an alkylidene carbene 1,5-CH insertion reaction as the key step. |
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