Ferrocenyl-QUINAP: a planar chiral P,N-ligand for palladium-catalyzed allylic substitution reactions |
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| Affiliation: | 1. Forschungszentrum Jülich GmbH, Jülich Centre for Neutron Science (JCNS), Outstation at Spallation Neutron Source (SNS), Oak Ridge National Laboratory, Oak Ridge, TN 37831-6473, USA;2. Chemical and Engineering Materials Division, Spallation Neutron Source, Oak Ridge National Laboratory, Oak Ridge, TN 37861-6475, USA;3. Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6100, USA |
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| Abstract: | The new planar chiral P,N-ligands 1a and 1b were prepared via a straightforward enantioselective synthesis using a Negishi cross-coupling and a sulfoxide/lithium exchange. Ligand 1a was successfully applied to Pd-catalyzed allylic alkylation (86% ee) and amination (83% ee) reactions. |
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