Microwave-assisted concise total syntheses of quinazolinobenzodiazepine alkaloids |
| |
Authors: | Liu Ji-Feng Kaselj Mira Isome Yuko Chapnick Jennifer Zhang Bailin Bi Grace Yohannes Daniel Yu Libing Baldino Carmen M |
| |
Institution: | ArQule, Inc., Division of Chemical Technologies, 19 Presidential Way, Woburn, Massachusetts 01801, USA. jliu@arqule.com |
| |
Abstract: | reactions: see text] One-pot total syntheses of the quinazolinobenzodiazepine alkaloids sclerotigenin (1), (+/-)-circumdatin F (2), and (+/-)-asperlicin C (3) via novel microwave-assisted domino reactions were achieved in 55%, 32%, and 20% yields, respectively, from commercially available starting materials. A two-step total synthesis of (+/-)-benzomalvin A (4) was accomplished with an overall yield of 16%. Additionally, analogues of circumdatin E were synthesized via the three-component one-pot sequential reactions promoted by microwave irradiation. Finally, a two-step formal total synthesis of (+/-)-asperlicin E (5) was also realized by using this microwave-assisted protocol. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|