Synthesis and characterization of organotitanium substituted heteropolytungstosilicates and their biological activity

Tris, di-( organotitanium) substituted tungstosilicates α,β - (CpTi)3(SiW₉037)^17– and γ-[(CpTi)2(SiW¹⁰O₃₈)] 6– were prepared by the reaction of C₂TiC1₂ (Cp= η-C₅H₅) with a,β-SiW₉ O9/34(noted α,β Siv₉,), γ-SiWO8/36 (noted γ-SiW₁₀) The products were characterized by means of elemental analysis, IR, ¹H NMR, ¹⁸³W NMR and polarography. ¹⁸³W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the A-XW₉ or γ-SiWl_O units. And the organotitanium substituted compounds showed promising in vitro antitumor activity in two of human tumor cell lines.