Highly enantioselective Michael additions of α-cyanoacetate with chalcones catalyzed by bifunctional cinchona-derived thiourea organocatalyst |
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| Institution: | 1. Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People’s Republic of China;2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | The conjugate addition of ethyl α-cyanoacetate with chalcones has been developed. In the presence of cinchona alkaloid-derived thiourea organocatalyst 1i (10 mol %), ethyl α-cyanoacetate could react with various chalcones to afford Michael adducts with high yields (80–92%) and enantioselectivities (83–95% ee). |
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