An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)

Affiliation:	1. Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA;2. Department of Chemical Process Development, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA;3. Department of Chemistry, P. M. Gross Chemical Laboratory, Duke University, Durham, NC 27708, USA;1. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran;2. Chemistry Department, Zhejiang University, Hangzhou 310027, PR China;1. Department of Chemistry, Ordu University, 52200 Ordu, Turkey;2. Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey;1. University of the Algarve, FCT, DQF and CEOT, 8005-139, Faro, Portugal;2. University of Puerto Rico, Rio Piedras Campus, PO Box 23343, San Juan, PR 00931-3343, USA

Abstract:	A short, high yielding, enantioselective synthesis of the novel H₃ agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-addition of a chiral N-propionyloxazolidinone to a nitroolefin.

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