VI. Synthesis of Heterocyclic Analogs of γ-Aminobutyric Acid from 3,5-Dinitrobenzoic Acid期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

VI. Synthesis of Heterocyclic Analogs of γ-Aminobutyric Acid from 3,5-Dinitrobenzoic Acid

Authors:	Shahkel'dyan I. V. Melekhina E. K. Atroshchenko Yu. M. Efremov Yu. A. Alifanova E. N. Kopyshev M. V. Troitskii N. A. Subbotin V. A. Nikishina M. B.

Affiliation:	(1) Tula State Pedagogical Universuty, Tula, 300026, Russia;(2) Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Tula, Russia

Abstract:	A series of 7-carboxy-3-R-1,5-dinitro-3-azabicyclo[3.3.1]non-6-enes was synthesized by reduction of 3,5-dinitrobenzoic acid with sodium borohydride followed by Mannich reaction with formaldehyde and primary amines. The mechanism of decomposition under electron impact of the 3-azabicyclo[3.3.1]nonane was established. Enthalpies of formation of compounds synthesized were calculated by semiempirical PM3 method.

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