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Regioselective ortho lithiation of halopyridines |
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| Authors: | Gordon W. Gribble Mark G. Saulnier |
| Affiliation: | Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755 U.S.A. |
| Abstract: | Regioselective ortho lithiation of 2-, 3-, and 4-halopyridines is achieved with lithium diisopropylamide (?78°, tetrahydrofuran) to afford, upon quenching with electrophilic reagents, 2,3- and 3,4-disubstituted pyridines in good to excellent yield. |
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