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Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine |
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| Authors: | Harding Wayne W Hodge Matthis Wang Zhixia Woolverton William L Parrish Damon Deschamps Jeffrey R Prisinzano Thomas E |
| Abstract: | The enantioselective synthesis of the (R,R)- and (S,S)-enantiomers of 1 from commercially available 3-chlorocinnamic acid is reported. The Sharpless asymmetric epoxidation was used to establish the stereocenters in the synthesis of both enantiomers of 1. |
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