Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities |
| |
| Authors: | Na Zhenkun Li Lin Uttamchandani Mahesh Yao Shao Q |
| |
| Affiliation: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore. |
| |
| Abstract: | A microarray immobilized with 105 aldehyde-containing small molecules was screened against mammalian cell lysates over-expressing cathepsin L to identify two potent inhibitors, which were subsequently converted into cell-permeable probes capable of live-cell imaging of endogenous cysteinyl cathepsin activities by two-photon fluorescence microscopy. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
