Synthesis of 4H-1,4-benzothiazine 1-oxide and 1,1-dioxide. Analogs of quinolone antibacterial agents |
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Authors: | Townley P Culbertson |
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Abstract: | 4-Cyclopropyl-5,7-difluoro-6-(4-methyl-1-piperazinyl)-4H-1,4-benzothiazine-2-carboxylic acid 1-oxide (2c) and 4-cyclopropyl-5,7-difluoro-6-(4-methyl-1-piperazinyl)-4H-1,4-benzothiazine-2-carboxylic acid 1,1-dioxide (2d) were prepared and assayed for antibacterial activity and inhibition of DNA gyrase. |
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