| 实时直接分析质谱的原理及应用 |
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| 引用本文： | 张佳玲,霍飞凤,周志贵,白玉,刘虎威.实时直接分析质谱的原理及应用[J].化学进展,2012(1):101-109. |
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| 作者姓名： | 张佳玲 霍飞凤 周志贵 白玉 刘虎威 |
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| 作者单位： | 北京分子科学国家实验室生物有机与分子工程教育部重点实验室北京大学化学与分子工程学院分析化学研究所 |
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| 基金项目： | 国家自然科学基金项目(No.21027012,20805001,21175008);中央高校基本科研业务费专项资金项目资助 |
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| 摘 要： | 新型常温常压离子化技术是近几年质谱学领域的一个研究热点。实时直接分析(direct analysis in real time,DART)作为该技术的一种,自2005年首次报道以来,已被应用于不同样品的分析。本文介绍了DART技术的发展过程、离子化机理以及影响DART离子化效率的参数,综述了其在活体果蝇费洛蒙检测、假药识别、墨水成分分析等方面的应用,并在结论部分对其应用前景进行了展望。
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| 关 键 词： | 常温常压离子化 实时直接分析 质谱 原理 |
The Principles and Applications of An Ambient Ionization Method——Direct Analysis in Real Time(DART) |
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| Zhang Jialing Huo Feifeng Zhou Zhigui Bai Yu Liu Huwei.The Principles and Applications of An Ambient Ionization Method——Direct Analysis in Real Time(DART)[J].Progress in Chemistry,2012(1):101-109. |
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| Authors: | Zhang Jialing Huo Feifeng Zhou Zhigui Bai Yu Liu Huwei |
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| Institution: | Zhang Jialing Huo Feifeng Zhou Zhigui Bai Yu** Liu Huwei(Beijing National Laboratory for Molecular Sciences,Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Institute of Analytical Chemistry,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China) |
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| Abstract: | The development of ionization approach has been focused on the ambient ionization methods in the past decade.DART was first reported by Cody and coworkers in 2005 and has been widely applied in the analysis of various samples including solids,liquids or gases.Helium or nitrogen is chosen as the working gas of DART.The working gas is activated by discharge needle and subsequently heated in the heating cell for the further sample ionization.The DART technology needs minimal or no sample pretreatmentand direct analysis can be carried out by holding sample in the localization between the outlet of DART and the entrance of mass spectrometer.This review presents the development,the ionization mechanism,and the major operation parameters of DART.And the applications in direct analysis of pheromones from live drosophila,screening of counterfeit drugs,identification of ingredient of inksand other samples are summarized.In the end,the technological limitations and development trends of DART are also discussed. |
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| Keywords: | ambient ionization methods direct analysis in real time(DART) mass spectrometry mechanism |
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