Synthesis and biological activity of some fluorinated arylhydrazotriazoles |
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| Authors: | SA Sadaphal PD Ghogare SG Gupta BB Shingate MS Shingare |
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| Institution: | 1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS, India;2. Department of Microbiology, Government Institute of Science, Aurangabad 431004, MS, India |
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| Abstract: | Potential biologically active derivatives of arylhydrazotriazole (3a–l) were prepared by the condensation reaction of diazonium salts using various aromatic amines (1a–l) and 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl) ethanones (2). The synthesized products were obtained in 75–85% yield. All the synthesized products were having good-excellent antifungal activity as compared with standard (Fluconazole and Ketoconazole) drugs. |
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| Keywords: | Fluorinated-arylhydrazotriazole Aromatic amines 1-(2 4-difluorophenyl)-2-(1H-1 2 4-triazol-1-yl) ethanones Diazonium salts Antifungal activity |
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