Cyclodextrins with heterocyclic substitution as GC stationary phases |
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Authors: | D -Q Xiao Y Ling R -N Fu J -L Gu A -Q Luo |
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Institution: | (1) Department of Chemical Engineering, Beijing Institute of Technology, 100081 Beijing, P. R. China |
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Abstract: | Summary Two new cyclodextrin (CD) derivatives, heptakis{2,6-di-O-pentyl-3-O-3′-(2″-chloro-4″,5″-dioxylmethene)-phenyl-5′-iso-oxazolylmethyl]}-β-CD
(CD I) and heptakis{2,6-di-O-methyl-3-O-3′-(2″-chloro)-phenyl-5′-iso-oxazolylmethyl]}-β-CD (CD II) were synthesized and coated
on fused-silica capillary columns. Their chromatographic characteristics, including column efficiency, polarity, selectivity
and phase transition were studied and compared with similar β-CD stationary phases. It was found that the heterocycle group
has a significant effect on the selectivity of the CD stationary phases. Both stationary phases can be successfully used to
separate many di- and trisubstituted benzene positional isomers and show stronger separation ability in separating low-polarity
benzene positional isomers than other β-CD stationary phases. |
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Keywords: | Gas chromatography Stationary phases Heterocyclic cyclodextrin derivatives Substituted benzene isomers |
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