| Oxone/CaCl_2/TEMPO体系在温和条件下对醇的氧化反应 |
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| 引用本文： | 陶晓春,曹雄杰,余伟,张钧陶.Oxone/CaCl_2/TEMPO体系在温和条件下对醇的氧化反应[J].有机化学,2010,30(2). |
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| 作者姓名： | 陶晓春 曹雄杰 余伟 张钧陶 |
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| 作者单位： | 1. 华东理工大学金属有机化学研究室,上海,200237
2. SH-Icon,Inc.,118 Peace Avenue,Bolingbrook,IL 60490,USA |
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| 摘 要： | Oxone/TEMPO/CaCl_2(TEMPO=2,2,6,6-Tetramethyl-1-piperidinyloxy)是一种稳定安全和易得的氧化催化体系,在室温条件下,可以氧化苄基或烷基醇生成醛或酮.苄基伯醇很容易被氧化成相应的醛,有较高的反应收率(90%～96%),仲醇氧化成相应的酮,收率在81%～85%之间,1,4-丁二醇环氧化生成γ-丁内酯得到了94%的收率.
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| 关 键 词： | 醇 氧化 |
Oxidation of Alcohols under Mild Conditions Using Oxone/CaCl_2/TEMPO |
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| Tao Xiaochun,Cao Xiongjie,Yu Wei,Zhang Juntao.Oxidation of Alcohols under Mild Conditions Using Oxone/CaCl_2/TEMPO[J].Chinese Journal of Organic Chemistry,2010,30(2). |
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| Authors: | Tao Xiaochun Cao Xiongjie Yu Wei Zhang Juntao |
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| Abstract: | An efficient catalytic oxidization using a stable and safe oxone/CaCl_2/TEMPO (TEMPO=2,2,6,6-Tetramethyl-1-piperidinyloxy) system to convert alkyl or benzyl alcohols to carbonyl compounds under room temperature is described. Primary benzyl alcohols are readily oxidized to the corresponding al-dehydes in excellent yields (90%～96%). Secondary alcohols are converted to corresponding ketones in 81%～85% yields. Oxidative cyclization of 1,4-diol to γ-lactone in 94% is obtained. |
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| Keywords: | Oxone CaCl_2 TEMPO oxone alcohol calcium chloride TEMPO oxidation |
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