| EFFECTS OF DEOXYCORTICOSTERONE ACETATE ON MUSCLE ELECTROLYTES,RESTING POTENTIAL AND MITOCHONDRIA IN RATS |
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| 作者姓名： | 蒋明明 朱培闳 黄世楷 于宗瀚 |
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| 作者单位： | Shanghai Institute of Physiology，Academia Sinica，Shanghai 200031，PRC，Shanghai Institute of Physiology，Academia Sinica，Shanghai 200031，PRC，Shanghai Institute of Physiology，Academia Sinica，Shanghai 200031，PRC，Shanghai Institute of Physiology，Academia Sinica，Shanghai 200031，PRC |
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| 摘 要： | Deoxycorticosterone acetate, injected daily for 5, 10, 20 or 30 days, reduced the serum potassium levels of rats by about 25%, a decrease that was independent of the treatment period employed. Serum sodium concentrations were unchanged with treatment duration. The potassium concentrations in extensor digitorum longus (EDL) and soleus (SOL) muscles were significantly decreased, and those of sodium increased, after treatment. Accompanying these changes of electrolyte concentration, the resting membrane potentials of treated EDL and SOL were hyperpolarized in vivo, and showed depolarization with the decreases of external potassium concentrations in vitro. The mitochondria in the muscles of treated rats were damaged. The degree of damage was more serious in EDL than in SOL and was dependent on the duration of deoxycorticosterone acetate treatment.
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EFFECTS OF DEOXYCORTICOSTERONE ACETATE ON MUSCLE ELECTROLYTES,RESTING POTENTIAL AND MITOCHONDRIA IN RATS |
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| JIANG MING-MING ZHU PEI-HONG HUANG SHI-KAI YU ZONG-HAN.EFFECTS OF DEOXYCORTICOSTERONE ACETATE ON MUSCLE ELECTROLYTES,RESTING POTENTIAL AND MITOCHONDRIA IN RATS[J].Science in China(Chemistry),1990(9). |
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| Authors: | JIANG MING-MING ZHU PEI-HONG HUANG SHI-KAI YU ZONG-HAN |
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| Abstract: | Deoxycorticosterone acetate, injected daily for 5, 10, 20 or 30 days, reduced the serum potassium levels of rats by about 25%, a decrease that was independent of the treatment period employed. Serum sodium concentrations were unchanged with treatment duration. The potassium concentrations in extensor digitorum longus (EDL) and soleus (SOL) muscles were significantly decreased, and those of sodium increased, after treatment. Accompanying these changes of electrolyte concentration, the resting membrane potentials of treated EDL and SOL were hyperpolarized in vivo, and showed depolarization with the decreases of external potassium concentrations in vitro. The mitochondria in the muscles of treated rats were damaged. The degree of damage was more serious in EDL than in SOL and was dependent on the duration of deoxycorticosterone acetate treatment. |
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| Keywords: | deoxycorticosterone acetate(DOCA) potassium sodium resting membrane potential mitochondria |
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