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Triterpene Acids from the Leaves of Planchonella Duclitan (Blanco) Bakhuizan
Authors:Tzong‐Huei Lee  Shin‐Hun Juang  Feng‐Lin Hsu  Cheng‐Yi Wu
Abstract:From the methanolic extract of the leaves of Planchonella duclitan, 2α,3α,19α,23‐tetrahydroxy‐13,27‐cyclours‐11‐en‐28‐oic acid (1), myrianthic acid (2), 2‐hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane‐type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF‐7 with IC50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.
Keywords:Planchonella duclitan  Sapotaceae  Leaves  Triterpene acids          19α    23‐tetrahydroxy‐13  27‐cyclours‐11‐en‐28‐oic acid  HT29  MCF‐7
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