Synthesis and antimycobacterial activity of alkyl 1‐heteroaryl‐1H‐1,2,3‐triazole‐4‐carboxylates |
| |
| Authors: | Bo&#x tjan Japelj,Simon Re
nik,Petra eba&#x ek,Branko Stanovnik,Jurij Svete |
| |
| Affiliation: | Boštjan Japelj,Simon Rečnik,Petra Čebašek,Branko Stanovnik,Jurij Svete |
| |
| Abstract: | A series of alkyl l‐heteroaryl‐1H‐1,2,3‐triazole‐4‐carboxylates 6a‐u were synthesised in four steps from methyl (Z)‐2‐benzyloxycarbonylarmino‐3‐(dimethylamino)prop‐2‐enoate ( 1 ) and heterocyclic amines 2a‐s. Triazoles 6a‐o were tested against antimycobacterial activity. For the most active compound, n‐pentyl 1‐(6‐phenylpyridazin‐3‐yl)‐1H‐1,2,3‐triazole‐4‐carboxylate ( 6n ), minimum inhibitory concentration 3.13 μg/ml was determined. |
| |
| Keywords: | |
|
|
