Synthesis and antimycobacterial activity of alkyl 1‐heteroaryl‐1H‐1,2,3‐triazole‐4‐carboxylates |
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| Authors: | Bo&#x;tjan Japelj Simon Re
nik Petra eba&#x;ek Branko Stanovnik Jurij Svete |
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| Institution: | Bo?tjan Japelj,Simon Re?nik,Petra ?eba?ek,Branko Stanovnik,Jurij Svete |
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| Abstract: | A series of alkyl l‐heteroaryl‐1H‐1,2,3‐triazole‐4‐carboxylates 6a‐u were synthesised in four steps from methyl (Z)‐2‐benzyloxycarbonylarmino‐3‐(dimethylamino)prop‐2‐enoate ( 1 ) and heterocyclic amines 2a‐s. Triazoles 6a‐o were tested against antimycobacterial activity. For the most active compound, n‐pentyl 1‐(6‐phenylpyridazin‐3‐yl)‐1H‐1,2,3‐triazole‐4‐carboxylate ( 6n ), minimum inhibitory concentration 3.13 μg/ml was determined. |
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