Synthesis and antimicrobial activity of 3‐(N‐arylamino)‐2‐phenyl‐naphtho[1,3‐d]‐1,2‐oxaphosphole 2‐oxides

The efficient preparation of cis‐3‐(N‐arylamino)‐2‐phenylnaphtho[1,3‐d]‐1,2‐oxaphosphole 2‐oxides 4 and 5 is described by a three‐component reaction involving phenyldichlorophosphine ( 2 ) 1‐hydroxy‐2‐naph‐thaldehyde/1‐hydroxy‐2‐acetonaphthone ( 1 ) and different substituted amines ( 3 ) in anhydrous benzene. The stereo structure, of the products ( 4 and 5 ), as well as the reaction mechanism of the cyclization is discussed. The title compounds ( 4 and 5 ) were fully characterized by NMR and mass spectral data. Their anti microbial activity was evaluated