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| (±)-Yaequinolone A2的简洁全合成 | |
| 引用本文： | 李欣昀 火星 李俊鹏 厍学功 潘鑫复. (±)-Yaequinolone A2的简洁全合成[J]. 中国化学, 2009, 27(7): 1379-1381. DOI: 10.1002/cjoc.200990230 |
| 作者姓名： | 李欣昀 火星 李俊鹏 厍学功 潘鑫复 |
| 作者单位： | (兰州大学化学化工学院 功能有机分子化学国家重点实验室 兰州 730000) |
| 摘 要： | 由廉价的邻氨基苯甲酸为起始原料经6步反应以27.8%的总产率首次合成了2-喹啉酮类生物碱(±)-yaequinolone A2，关键步骤为MOM保护的α-羟基酰胺进行的高非对映选择性分子内aldol 反应。 |
| 关 键 词： | (±)-yaequinolone A2 N-sulfinylaniline aldol反应 |
| 收稿时间： | 2008-10-13 |
| 修稿时间： | 2008-12-11 |
A Concise Synthesis of (±)‐Yaequinolone A2 |
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| Xinyun LI,Xing HUO,Junpeng LI,Xuegong SHE,Xinfu PAN. A Concise Synthesis of (±)‐Yaequinolone A2[J]. Chinese Journal of Chemistry, 2009, 27(7): 1379-1381. DOI: 10.1002/cjoc.200990230 | |
| Authors: | Xinyun LI Xing HUO Junpeng LI Xuegong SHE Xinfu PAN |
| Affiliation: | 1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China;2. Tel.: 0086‐0931‐8912276;3. Fax: 0086‐0931‐8912582 |
| Abstract: | A concise total synthesis of (±)‐yaequinolone A2 ( 2 ), a 2‐quinolone alkaloid, has been accomplished through 6 steps from anthranilic acid with an overall yield of 27.8%. The synthetic strategy exploits highly diastereoselective intramolecular aldol addition of the MOM protected α‐hydroxyanilide 7 as the key step. |
| Keywords: | (±)‐yaequinolone A2 N‐sulfinylaniline aldol reaction |
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