| 6-氯吲哚酮的含量测定研究 |
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| 引用本文： | 刘星星,杨建设,杨艺虹,孙佳,张珩,张秀兰.6-氯吲哚酮的含量测定研究[J].分析测试技术与仪器,2009,15(1):18-20. |
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| 作者姓名： | 刘星星 杨建设 杨艺虹 孙佳 张珩 张秀兰 |
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| 作者单位： | 1. 武汉工程大学,湖北省新型反应器与绿色化学工艺重点实验室,湖北,武汉,430073
2. 武汉工程大学,绿色化工工程省部共建重点实验室,湖北,武汉,430073 |
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| 摘 要： | 以无水乙醇作为溶剂，用紫外分光光度法测定盐酸齐拉西酮的重要中间体6-氯吲哚酮的含量．测得6-吲哚酮对照品溶液浓度在0．0048～0．0200mg／mL范围之内线性关系良好，其线性方程为Y=41．484X＋0．007（R^2=0．9994）．平均回收率为99．11％，RSD为0．53％（n=6），结果说明方法简便、灵敏、准确，重现性好．
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| 关 键 词： | 6-氯吲哚酮 盐酸齐拉西酮 中间体 紫外分光光度法 |
Study on Content of 6-Chlorooxindole |
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| LIU Xing-xing,YANG Jian-she,YANG Yi-hong,SUN Ji,ZHANG Heng,ZHANG Xiu-lan.Study on Content of 6-Chlorooxindole[J].Analysis and Testing Technology and Instruments,2009,15(1):18-20. |
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| Authors: | LIU Xing-xing YANG Jian-she YANG Yi-hong SUN Ji ZHANG Heng ZHANG Xiu-lan |
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| Institution: | 1.Hubei Key Labotatory of Novel Chemical Reactor & Green Chemical Technology;Wuhan Institute of Techology;Wuhan 430073;China;2.Key Laboratory for Green Chemical Process of Ministry;Wuhan Institute of Technology;China |
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| Abstract: | The 6 - Chlorooxindole content, an important intermediate of Ziprasidone, has been determined by the UV spectrophotometry, Ethanol was chosen as the solvent. The concentration vs absorbance was linear in the range of 0. 0048 - 0.02mg/ mL,the equation of linear regression was Y = 41. 484X ＋ 0. 007 （R^2 =0. 9994）. The average recovery was 99.11%, and RDS was 0.53% （n =6）. The results show that this method is simple,sensitive,accurate and reproducible. |
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| Keywords: | 6-chlorooxindole ziprasidone intermediate UV spectrophotometry |
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