NHC triggered cascade metal-free synthesis of 2,3-diarylated indoles under solvent-free conditions |
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| Authors: | Changsheng Yao Donglin WangJun Lu Bingbin QinHonghong Zhang Tuanjie LiChenxia Yu |
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| Affiliation: | a School of Chemistry and Engineering, Key Laboratory of Biotechnology for Medicial Plant, Xuzhou Normal University, Xuzhou, Jiangsu 221116, PR China
b School of Chemistry and Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, Xuzhou, Jiangsu 221116, PR China |
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| Abstract: | A new cascade strategy to the synthesis of 2,3-diarylated indoles via the metal-free reaction of aryl aldehyde and aryl amine triggered by N-heterocyclic carbene (NHC) under solvent-free conditions, has been disclosed. The protocol has the advantages of easy work-up, high yields, wide application scope, and an environmentally benign procedure compared with the reported methods. |
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| Keywords: | Cascade reaction Indoles NHC Solvent-free synthesis |
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