Oxidation of 4-nitro-<Emphasis Type="Italic">o</Emphasis>-xylene with nitric acid using <Emphasis Type="Italic">N</Emphasis>-hydroxyphthalimide under phase transfer conditions |
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| Authors: | Song-Bo Wei Bo Tang Xin-Hua Peng |
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| Institution: | 1.School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing,China |
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| Abstract: | 4-Nitro-o-xylene was selectively oxidized to 2-methyl-4-nitrobenzoic acid using dilute nitric acid as the oxidizing agent under atmospheric pressure. The oxidation of 4-nitro-o-xylene was effectively promoted by an addition of radical initiators. Under reflux, 2-methyl-4-nitrobenzoic acid was afforded in high yield using nitric acid combined with N-hydroxyphthalimide, cobalt dichloride (CoCl2 · 6H2O), manganese acetate (Mn(OAc)2 · 4H2O) and phase transfer catalyst. |
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