LC–MS–MS Quantification of Four Quinoxaline-1,4-Dioxides in Swine Feed |
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Authors: | Cong-Ming Wu Yan Li Jian-Zhong Shen Lin-Li Cheng Yan-Shen Li Chun-Yan Yang Pei-Sheng Feng Su-Xia Zhang |
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Institution: | 1. Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, 100193, Beijing, People’s Republic of China
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Abstract: | A sensitive and reliable method by liquid chromatography–tandem mass spectrometry was developed for the simultaneous determination of carbadox, mequindox, olaquindox and quinocetone in swine feed. The analytes were extracted from swine feed with acetonitrile/water (60:40, v/v), and then further purified by solid-phase extraction using Oasis HLB cartridges. The mean recovery values ranged from 83–108%, and intra-day and inter-day variation were <10.8 and 9.6%, respectively. The limits of quantification for the four compounds were <20 μg kg?1. This procedure is applicable for detecting the four quinoxaline-1,4-dioxides in swine feed. |
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