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Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite |
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| Authors: | Darko Kwabena Adu Zondi Nate John Alake Blessing Wisdom Ike Ruchika Chauhan Prof Rajshekhar Karpoormath |
| Institution: | 1. Department of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000 South Africa;2. Department of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000 South Africa
Department of Biotechnology & Chemistry, Faculty of Applied and Computer Sciences, Vaal University of Technology, Vanderbijlpark, 1900 South Africa |
| Abstract: | Solvothermally synthesized cobalt sulphide/reduced graphene oxide (CoS/rGO) was used to fabricate an electrochemical sensor for detection of artemisinin. Microscopic techniques were used to characterize CoS/rGO nanocomposite. The electrochemical sensor was fabricated by modifying the surface of glassy carbon electrode with CoS/rGO nanocomposite. Fe(CN)6]3−/4− was used as a mediator to aid oxidation of artemisinin. Differential pulse voltammetric technique was used for the detection of artemisinin. A linear range of 30–100 μM was used. Experimentally, a detection limit of 0.5 μM was obtained. Therefore, the developed sensor can be used for quality control of artemisinin. |
| Keywords: | Artemisinin Cobalt sulphide reduced graphene oxide Differential pulse voltammetry and solvothermal method |