Novel one pot synthesis of substituted quinazolin-4(3H)-ones and pyrazolo[4,3-d]pyrimidin-7(6H)-ones using copper iodide,azides and terminal alkynes |
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| Authors: | V Srishyalam N Devanna MV Basaveswara Rao Naveen Mulakayala |
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| Institution: | 1. Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India;2. Department of Chemistry, Krishna University, Machilipatnam 521 00, India;3. Clearsynth Labs Ltd, Plot No-177, IDA Mallapur, Nacharam, Hyderabad 500076, India |
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| Abstract: | A simple and highly efficient copper iodide catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones have been developed from anthranilamide, terminal alkynes and azides. A wide variety of alkynes were screened to understand the scope of this methodology. This method has been extended for the synthesis of 5-substituted pyrazolo4,3-d]pyrimidin-7(6H)-ones which are having potential applications in medicinal chemistry. |
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| Keywords: | Azides Copper iodide Terminal alkynes |
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