Synthesis of 2,3,6-trisubstituted pyridines by transition-metal free cyclization of 1,3-diynes with amino acids |
| |
| Authors: | Gang Zhou Xiaoming Zhao Wenyan Dan |
| |
| Affiliation: | State Key Laboratory of Pollution Control and Resource Reuse, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, 200092 Shanghai, PR China |
| |
| Abstract: | ![]()
Amino acids are firstly employed in transition-metal free heterocyclization reaction of 1,3-diynes in the presence of K3PO4 and DMSO at 120 °C. This method produces 2,3,6-trisubstituted pyridines with up to 86% yield. The –CO2H group on the amino acids is crucial for this heterocyclization reaction. The mechanism of such a heterocyclization reaction is discussed, as well. |
| |
| Keywords: | Amino acid 1,3-Diyne Cyclization Pyridine Transition-metal free |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
