纳米生物无机界面的构筑与循环肿瘤细胞分离

纳米生物无机界面的研究是无机化学学科新兴的前沿领域之一。纳米结构的无机材料在仿生界面、细胞界面、生物检测界面等领域扮演着越来越重要的角色。近几年来,无机纳米结构被尝试用于痕量循环肿瘤细胞(Circulating Tumor Cells,CTCs)分离的基础探索研究中,并展现出非常吸引人的应用前景。痕量CTCs的高效分离对于癌症早期检测、术后监测及生物学研究等具有重要的意义。本文主要综述纳米生物无机界面在CTCs分离中的应用,详细介绍其发展现状,并对未来做一展望。

Construction of Nanostructured Inorganic Biointerface towards Highly Efficient Isolation of Circulating Tumor Cells

Constructions and applications of nanostructured inorganic biointerface is one of the new emerging research fronts of inorganic chemistry. Nanostructured inorganic materials are showing their important roles in areas such as biomimetic interface, cell interface, and biological detection. Recently, inorganic nanostructures have been exploringly applied for the fundamental study of trace circulating tumor cells (CTCs) isolation. The isolation of trace CTCs is very important for the early diagnosis and prognosis monitor of cancer, and the study of cancer biology, etc. In this review, we mainly focus on the construction of nanostructured inorganic biointerface for trace CTCs isolation. The research progress is summarized and the future prospect is discussed.