Thermal and dissolution kinetics of ampicillin drug and capsules |
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Authors: | Barręto Gomes A P Souza F S Macędo R O |
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Institution: | (1) Universidade Federal da Paraíba - UFPB Unidade de Desenvolvimento e Ensaios de Medicamentos, UDEM Cidade Universitária Campus I, LTF, Joăo Pessoa, Paraíba, Brasil;(2) Unidade de Desenvolvimento e Ensaios de Medicamentos/Laboratório de Tecnologia Farmacęutica-Universidade Federal da Paraíba-Campus I-Joăo, Pessoa Paraíba, ZIP 58059-900, Brasil |
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Abstract: | This work aims to compare the thermal decomposition and dissolution kinetics of ampicillin drug and products A, B and C. The thermal decomposition reaction rate constants (kT) were determined by isothermal thermogravimetric method using the classical Arrhenius equations. The dissolution profiles
were obtained using USP 23 method and rate constants (kD) were determined by Kitazawa equation. The results showed correlation between kT and kD can be used in the study of preformulation of drugs and also as a parameter in the studies of pharmaceutical equivalence.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | ampicillin pharmaceutical equivalence kinetic |
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