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Thiazolecarboxylic Acid Derivatives. 1. N-Substituted 2-Amino-4-methylthiazole-5-carboxylic Acid Derivatives
Authors:V V Dovlatyan  K A Eliazyan  V A Pivazyan  E A Kazaryan  A P Engoyan
Institution:(1) Armenian Agricultural Academy, Yerevan, 375009, Armenia
Abstract:Acylation of the ethyl ester and anilide of 2-amino-4-methylthiazole-5-carboxylic acid gave 2-acetyl(arylsulfonyl)amino derivatives. Methylation of acetylaminothiazole and subsequent deacetylation gave 2-methylamino-4-methylthiazole-5-carboxylic acid, which was then converted into esters. The ethyl ester and anilide of thiazole-2-carboxylic acid were used as starting compounds for the synthesis of 2-dimethylaminoformimino- and 2-chlorobenzenesulfonylureido derivatives.
Keywords:aminoformiminothiazole  acylaminoformiminothiazole  dimethylaminoformiminothiazole  thiazole-5-carboxylic acid  thiazole-5-carboxylate esters
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